Correction of gastrointestinal microbiocenosis and nutritional status in patients with metabolic syndrome and intestinal dysbiosis of individually selected probiotics

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The article presents the study of the evaluation of the correction of intestinal microbiocenosis and nutritional status disorders in patients with metabolic syndrome and intestinal dysbiosis after treatment with individually selected probiotics and probiotic foods. The study involved 117 patients with metabolic syndrome and intestinal dysbiosis 1-2 degrees, living in the therapeutic area. 3 observation groups were formed. The main criteria for assigning patients to different groups of observations were the difference in adhesion, biocompatibility and the degree of antagonism of microorganisms isolated in the faeces. Results of the correction of intestinal microbiocenosis of patients were evaluated for microbiological indicators faeces, correction of nutritional status - in terms of body composition, blood lipids and glucose profiles. Treatment with individually selected probiotics with high adhesion and antagonism, not suppress indigenous lactobacilli and bifidobacteria in the background contributed to the hypocaloric diet correction microbiological parameters in the feces, body composition and biochemical indicators of lipid and carbohydrate spectrum of the blood of patients.

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About the authors

D V Kopchak

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.

Russian Federation

V V Zakrevskii

North-Western State Medical University named after I.I. Mechnikov


Russian Federation


  1. Ардатская М.Д., Бельмер С.В., Доброица В.П. Дисбиоз (дисбактериоз) кишечника: современное состояние проблемы, комплексная диагностика и лечебная коррекция // Экспериментальная и клиническая гастроэнтерология. — 2015. — № 5. — С. 13–50. [Ardatskaya MD, Bel’mer SV, Dobritsa VP, et al. Colon dysbacteriosis (dysbiosis): modern state of the problem, comprehensive diagnosis and treatment correction. Eksperimental’naya i klinicheskaya gastroenterologiya. 2015;(5):13-50. (In Russ.)].
  2. Метаболический синдром / В. Фонсека и др. Пер. с англ. — М.: Практика, 2011.— 272 с. [Metabolicheskiy sindrom. Moscow: Praktika; 2011. 272 p. (In Russ.)].
  3. Cani PD, Delzenne NM. Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care. 2007;(10):729-734. doi: 10.1097/MCO.0b013e3282efdebb.
  4. David LA, Maurice CE, Carmody RN. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-563. doi: 10.1038/nature12820.
  5. D’Aversa F, Tortora A, Laniro G. Gut microbiota and metabolic syndrome. Inter Emerg Med. 2013;8(Suppl 1):11-15.
  6. Festi D, Schiumerini R, Eusebi LH, et al. Gut microbiota and metabolic syndrome. World J Gastroenterol. 2014;20(43):16079-16094. doi: 10.3748/wjg.v20.i43.16079.
  7. ОСТ 91500.11.004 2003. Протокол ведения больных. Дисбактериоз кишечника. Утвержден приказом Минздрава РФ № 231 от 9 июня 2003. [OST 91500.11.004 2003. Protokol vedeniya bol’nykh. Disbakterioz kishechnika. Utverzhden prikazom Minzdrava RF No 231 ot 9 iyunya 2003. (In Russ.)].
  8. Патент № 2428468 РФ: Оришак Е.А., Нилова Л.Ю., Бойцов А.Г.; № 2010122714; заявл. 10.09.2011; опубликовано10.09.2011, бюл. № 25. Способ индивидуального подбора пробиотических препаратов, содержащих лактобактерии и/или бифидобактерии, для элиминации условно-патогенных микроорганизмов, выделенных от пациента при исследовании на дисбактериоз кишечника. [Patent No 2428468 RF: Orishak E.A., Nilova L.Yu., Boytsov A.G.; № 2010122714; zayavl. 10.09.2011; opublikovano10.09.2011, byul. № 25. Sposob individual’nogo podbora probioticheskikh preparatov, soderzhashchikh laktobakterii i/ili bifidobakterii, dlya eliminatsii uslovno-patogennykh mikroorganizmov, vydelennykh ot patsienta pri issledovanii na disbakterioz kishechnika. (In Russ.)].



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Copyright (c) 2016 Kopchak D.V., Zakrevskii V.V.

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