Calciphylaxis in kidney graft recipient with type 1 diabetes: A case report

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Abstract

Calcifylaxis — calcifying uremic arteriolopathy — is a rare disease that occurs in patients with chronic kidney disease and is characterized by progressive calcification of small-caliber skin vessels and thrombosis of small (arterioles), accompanied by necrosis of the skin, subcutaneous tissue and soft tissues with severe pain syndrome. The article describes a patient with a long-term, severe course of diabetes mellitus, the development of diabetic nephropathy with an outcome in terminal renal failure, which required renal replacement therapy with peritoneal dialysis and kidney transplantation. In the posttransplantation period, the patient registered the occurrence of calcifylaxis, which is a rare complication.

The lack of treatment protocols for calcifylaxis in patients with chronic kidney disease requires further research. It is important to constantly monitor patients with risk factors for the development of this serious disease and timely treatment, which will improve their condition and slow down the progression of the process.

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About the authors

Valentina V. Polykova

North-Western State Medical University named after I.I. Mechnikov

Email: valentina.polyakova@szgmu.ru
ORCID iD: 0000-0001-9148-4546

md, cand. sci. (med.), assistant professor

Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015

Irina Yu. Matezius

North-Western State Medical University named after I.I. Mechnikov

Email: imatezius@yandex.ru
ORCID iD: 0000-0002-8694-9756

md, cand. sci. (med.), assistant professor

Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015

Elizaveta V. Fomina

North-Western State Medical University named after I.I. Mechnikov

Email: 4891190@mail.ru
ORCID iD: 0009-0002-4905-1573
Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015

Zakhar V. Lopatin

North-Western State Medical University named after I.I. Mechnikov

Email: zakhar.lopatin@szgmu.ru
ORCID iD: 0000-0001-7283-9911

md, cand. sci. (med.), assistant professor

Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015

Elena V. Semenova

North-Western State Medical University named after I.I. Mechnikov

Email: elenalokb@yandex.ru
ORCID iD: 0000-0003-2955-9097

md, cand. sci. (med.), assistant professor

Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015

Irina V. Ulyankina

Academician I.P. Pavlov First St. Petersburg State Medical Universitya; Saint Petersburg Scientific Research Institute of Emergency Medicine named after. I.I. Dzhanelidze

Author for correspondence.
Email: spb.yl@mail.ru
ORCID iD: 0000-0001-9207-520X

md, cand. sci. (med.)

Russian Federation, Saint-Petersburg

References

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Supplementary files

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2. Fig. 1. Patient E. Necrosis in the area of the terminal phalanx of the IV finger of the right hand

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3. Fig. 2. Patient E. X-ray of the hands (vascular calcification)

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