Annexins and their role in the control of symbioses development in plants

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Annexins belong to the superfamily of calcium-dependent phospholipid binding proteins. The participation of these proteins in the regulation of structural organization of membranes, vesicular transport and a variety of signal transduction pathways is important for many cellular processes. Despite the structural similarity with animal annexins, plant annexins are characterized by significant variability of the N-terminal region and modification of calcium-binding motifs in II and III repeats, while calcium-binding motifs in I and IV repetitions remain conservative. However, the physiological role of animal and plant annexins, as well as mechanisms of their influence on calcium metabolism, may be similar. This review focused on the latest data about the structure and functioning of plant annexins.

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About the authors

Darya V. Kustova

Federal State Budget Scientific Institution All-Russia Research Institute for Agricultural Microbiology


Russian Federation, Saint Petersburg

младший научный сотрудник

Elena A. Dolgikh

Federal State Budget Scientific Institution All-Russia Research Institute for Agricultural Microbiology

Author for correspondence.
ORCID iD: 0000-0002-5375-0943
SPIN-code: 4453-2060
Scopus Author ID: 6603496335
ResearcherId: G-6363-2017

Russian Federation, Saint Petersburg

Doctor of Sciences, Head, Laboratory of Signal Regulation


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Supplementary files

Supplementary Files Action
Figure: 1. Comparative analysis of amino acid sequences of two Medicago truncatula annexins MtAnn1 (NCBI CAD29698.1), MtAnn2 (NCBI AES68900.1), and two annexins Phaseolus vulgaris PvAnn1 (NCBI Phvul.011G209300.1), PvAnn2 (NCBI Phvul.1.0) ... The four annexin repeats are underlined and marked with Roman numerals I – IV. Potential calcium-binding motifs are highlighted in gray. In the first annexin repeat, conserved tryptophan is noted, which is necessary for binding to the membrane

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Figure: 2. The spatial structure of the M. truncatula annexin MtAnn2 was constructed using the Modeller 9.20 program. using cotton Gossypium hirsutum (PDB code P93157) as a template for annexin GhAnn1 3D structure. The structure was visualized using the PyMol program

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Copyright (c) 2020 Kustova D.V., Dolgikh E.A.

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