Genotoxic biomarkers in patients on hemodialiasis

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Abstract


It is generally recognized that genotoxic damage have essential etiopathogenetic significance, and its prevention is an important measure to preserve human life and health. In the framework of this concept, literature information on studies of genotoxic biomarkers in patients with various hemodialysis regiments has been reviewed and summarized, and ways to prevent detectable genotoxicity have been identified. Based on the analysis of the known data, it was concluded that patients of this group have an increased level of DNA and chromosome damage in peripheral blood lymphocytes. Based on the results of individual studies, it was shown that one of the strategies for reducing genotoxicity may be the improvement of hemodialysis therapy methods and regimes, as well as pharmacological and nutritional correction of genotoxic effects.


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About the authors

Natalia V. Eremina

Zakusov Research Institute of Pharmacology

Author for correspondence.
Email: neremina@panacelalabs.com
ORCID iD: 0000-0002-7226-5505
SPIN-code: 5224-1968

Russian Federation, Moscow

Cand. Sci. (Biol.) Senior Research Associate of Laboratory of Drug Toxicology

Andrey D. Durnev

Zakusov Research Institute of Pharmacology

Email: addurnev@mail.ru
ORCID iD: 0000-0003-0218-8580
SPIN-code: 8426-0380
Scopus Author ID: 7006060753
ResearcherId: S-7428-2016

Russian Federation, Moscow

Dr. Sci. (Med.), Professor, Corresponding Member of RAS

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Supplementary files

Supplementary Files Action
1.
Figure: 1. Frequency of micronuclei in lymphocytes of patients on hemodialysis therapy and control groups, mean ± SEM (n = 7, p <0.05)

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2.
Figure: 2. Correlation of the frequency of micronuclei (MN) in binucleated lymphocytes in patients undergoing hemodialysis and control groups. Each point on the graph represents the mean for one study (n = 7)

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