Analysis of the association of polymorphic markers of dopaminergic (DRD2/ANKK1) and serotonergic (HTR2A) systems in the brain with the personality traits of adolescents



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Abstract

The studies of personality characteristic of young adolescents caused by their genetic predispositions have become very essential in recent years. In our study we have investigated the association of dopamine (D2) and serotonin (2A) receptor genes with personality traits in 360 young adults. We have found the influence of the combination of DRD2/ANKK1 and HTR2A genes on the personality traits measured on Rule-Consciousness and Self-Reliance scales in girls. The significant statistical difference on Self-control scale was established for polymorphism TaqIA of gene DRD2/ANKK1 in boys. Additionally, the differences on Social Boldness scale were observed after stratification of genotypes DRD2/ANKK1 and HTR2A.

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About the authors

Vladimir I Barsky

A.N. Sysin Scientific Research Institute of Human Ecology and Hygien of Environment, Moscow, RF

Email: wib@list.ru

Marina G Aksenova

A.N. Sysin Scientific Research Institute of Human Ecology and Hygien of Environment, Moscow, RF

Email: sibr@yandex.ru

Olga B Kozlova

A.N. Sysin Scientific Research Institute of Human Ecology and Hygien of Environment, Moscow, RF

Email: olga.kozlova@gmail.com

Andrey V Kirillov

A.N. Sysin Scientific Research Institute of Human Ecology and Hygien of Environment, Moscow, RF

Email: ak_huji@mail.ru

Andrey A Demin

A.N. Sysin Scientific Research Institute of Human Ecology and Hygien of Environment, Moscow, RF

Email: komus@bk.ru

Lubov M Ilinykh

Education Centre № 1998, Moscow, RF

Email: psi1998@mail.ru

Irina K Rapoport

Research Institute of Hygiene and Health of children and adolescents, Moscow, RF

Email: rapoportik@rambler.ru

Aliy U Asanov

I.M. Sechenov Moscow Medical Academy, Moscow, RF

References

  1. Анохина И. П., Иванец Н. 1. Н., Шамакина И. Ю. и др., 2004. Современные проблемы генетики зави- симости от психоактивных веществ // Нарколо- гия. № 6.
  2. Бурлачук Л. Ф., Королев Д. К., 2000. Адаптация опросника для диагностики пяти факторов личности // Вопросы психологии. № 1. С. 126-134.
  3. Голимбет В. Е., Алфимова М. В., Митюшина Н. Г., 2004. Полиморфизм гена рецептора серотонина (HTR2A) и особенности личности // Молекулярная биология. Т. 38. № 3. С. 404-412.
  4. Демин А. А., Сотникова Е. Н., Аксенова М. Г.,
  5. Ильиных Л. М., 2006. Роль генетических факторов в дезадаптивном поведении подростков // Журнал Гигиена и санитария. № 5. С. 76-77.
  6. Кибитов А. О., Воскобоева Е. Ю., Моисеев И. А. и др., 2007. Сравнительный анализ вариантов полиморфизма генов дофаминовых рецепторов DRD2/ ANKK1 и DRD4 у больных с зависимостью от разных видов ПАВ // Наркология. № 4.
  7. Райгородский Д. Я . и др., 2000. Практическая психодиагностика. Самара: Бахрам-М, 672 с.
  8. Шнайдер Л. Б., 2007. Девиантное поведение детей и подростков. M.: Академический проект, Трикста, 336 с.
  9. Beaver K. M., Wright J. P., DeLisi M. et al., 2007. A gene × gene interaction between DRD2/ANKK1 and DRD4 is associated with conduct disorder and antisocial behavior in males // Behavior Brain Function. Vol. 3. P. 30.
  10. Benjamin J., Osher Y., Lichtenberg P. et al., 2000. An Interaction between the Catechol OMethyltransferase and Serotonin Transporter Promoter Region Polymorphisms Contributes to Tridimensional Personality Questionnaire Persistence Scores in Normal Subjects // Neuropsychobiology. Vol. 41. P. 48-53.
  11. Chee I. S., Lee S. W., Kim J. L. et al., 2001. 5-HT2A receptor gene promoter polymorphism-1438A/G аnd bipolar disorder // Psychiatric Genetic. Vol. 11. P. 111-114.
  12. Choi M. J., Lee H. J., Lee H. J. et al., 2004. Association between major depressive disorder and the -1438A/G polymorphism оf the serotonin 2A receptor gene // Neuropsychobiology. Vol. 49. P. 38-41.
  13. Cloninger C. R., 1987. A systematic method for clinical description and classification of personality variants // Arch Gen Psychiatry. Vol. 44. P. 573-588.
  14. Cloninger C. R., Svrakic D., Przybeck T., 1993. A psychobiological model of temperament and character // Archives of General Psychiatry. Vol. 50. P. 975-990.
  15. Costa P. T., Jr., McCrae R. R., 1992. Normal personality assessment in clinical practice: The NEO Personality Inventory // Psychological Assessment. Vol. 4. P. 5-13.
  16. Doug Hyun Han, Sujung J. Yoon, Young Hoon Sung et al., 2008. A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence // Comprehensive Psychiatry. Vol. 49. P. 387-392.
  17. Ebstein R., Novick O., Umansky R. et al., 1996. Dopamine D4 receptor (DRD4) exon III polymorphism associated with the human personality trait of novelty seeking // Nature Genetics. Vol. 12. P. 78-80.
  18. Eisenberg D., Campbell B., MacKillop J. et al., 2007. Polymorphisms in the Dopamine D4 and D2 Receptor Genes and Reproductive and Sexual Behaviors // Evolutionary Psychology. Vol. 5, N 4. P. 696- 715. URL: www.epjournal.net (дата обращения: 08.09.2009).
  19. Fiocco A. J., Joober R., Judes P., Sonia L., 2007. Polymorphism of the 5-HT2A receptorgene: Association with stress-related indices in healthy middle-aged adults // Frontiers in Behavioral Neuroscience. Vol. 1, Article 3.
  20. Guimarães A., Zeni C., Polanczyk G. et al., 2006. Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: Preferential transmission of the HTR2A 452His allele to affected boys // American Journal of Medical Genetics. Vol. 144B Issue 1. P. 69 - 73.
  21. Hao-Yang Tan, Qiang Chen, Sust S. et al., 2007. Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function // PNAS July 24, Vol. 104. N. 30. P. 12536-12541.
  22. Hull E. M., Muschamp J. W., Sato S, 2004. Dopamine and serotonin: influences on male sexual behavior // Physiology & Behavior. Vol. 83. P. 291-307. 22. Hünnerkopf R., Strobel A., Gutknecht L., Brocke B.,
  23. Lesch K. P., 2007. Interaction between BDNF Val66- Met and dopamine transporter gene variation influences anxiety-related traits // Neuropsychopharmacology. Vol. 32, N 12. P. 2552-2560.
  24. Jose Perez de los Cobos, Baiget M., Trujols J. et al., 2007. Allelic and genotypic associations of DRD2/ ANKK1 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study // Behavioral and Brain Functions. Vol. 3. P. 25.
  25. Lahti R. A., Lahti A. C., 1997. Images in neuroscience. Clinical genetics. Association of genetic and personality characteristics // Am. J. Psychiatry. Vol. 154. N 11. P. 1496.
  26. Љerэ O., Znojil V., Hrabбnek M., Vojtovб V., Zvolskэ P. Association study between the D2 dopamine receptor A1 allele and amphetamine dependence. URL: http:// www.lf2.cuni.cz/physiolres/feps/thu_oral.htm (дата обращения: 08.09.2009).
  27. Light K. J., Joyce P. R., Luty S. E. et al., 2007. An association study of DRD2/ANKK1 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients // Behavioral and Brain Functions. Vol. 3. P. 3
  28. Munafo M., Clark T., Moore L. et al., 2003. Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis // Molecular Psychiatry. Vol. 8. P. 471-484.
  29. Noble E. P., Ozkaragoz T. Z., Ritchie T. L. et al., 1998. D_2 and D_4 dopamine receptor polymorphisms and personality // American Journal of Medical Genetics. Vol. 81, N 3. P. 257-267.
  30. Parker G. B., Brotchie H. L., 2004. From Diathesis to Dimorphism // The Biology of Gender Differences in Depression
  31. Pelissolo A., Corruble E., 2002. Personality factors in depressive disorders: contribution of the psychobiologic model developed by Cloninger // Encephale. Vol. 28. P. 363-373.
  32. Pohjalainen T., Rinne J., Någren K. et al., 1998. Sex Differences in the Striatal Dopamine D2 Receptor Binding Characteristics in vivo // Am. J. Psychiatry. Vol. 155. P. 768-773.
  33. Reuter M., Schmitz A., Corr P., Hennig J., 2006. Molecular genetics support Gray's personality theory: the interaction of COMT and DRD2/ANKK1 polymorphisms predicts the behavioral approach system // Neuropsychopharmacol. Vol. 9, N 2. P. 155-166.
  34. Roberts B., Walton K., Viechtbauer W., 2006, Psychological Bulletin. Vol. 132, N 1. P 29-32
  35. Romans S. E., 2000; Gender Issues In Psychiatry // Hong Kong J. Psychiatry. Vol. 10, N 4. P. 7-11.
  36. Trimble M. R., 1996, Biological Psychiatry. L.: John Wiley and Sons.
  37. Urwin R. E., Bennetts B. H., Wilcken B. et al., 2003. Gene-gene interaction between the monoamine oxidase A gene and solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2 gene in anorexia nervosa (restrictive subtype) // European Journal of Human Genetics. Vol. 11. P. 945-950.
  38. Wacker J., Reuter M., Hennig J., Stemmler G., 2005. Sexually dimorphic link between dopamine D2 receptor gene and neuroticism-anxiety // Neuroreport. Vol. 16, N 6. P. 611-614.
  39. Wangt Tso-Jen, Huang San-Yuan, Lint Wei-Wen et al., 2007. Possible interaction between MAOA and DRD2/ANKK1 genes associated with antisocial alcoholism among Han Chinese men in Taiwan // Progress in neuro-psychopharmacology & biological psychiatry. Vol. 31, № 1. P. 108-114.

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Copyright (c) 2010 Barsky V.I., Aksenova M.G., Kozlova O.B., Kirillov A.V., Demin A.A., Ilinykh L.M., Rapoport I.K., Asanov A.U.

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