«Ageingfeatures» analysis of IGF-1 and PGC-1 genes polymorphism

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Abstract


Our goal was to investigate whether a polymorphism in IGF-1 gene (wild-type, 192 base pairs) and in the PGC-1 gene (Gly482Ser polymorphism) influence life expectancy. Different distribution of IGF-1 (CA repeats) gene polymorphism was shown. Increasing of 20/- genotype in elderly people compared with newborn group (26,7 and 44,1 %, accordantly, ϰ2 = 8,57, p = 0,0034) and decreasing of 19/19 genotype (51 and 27,9%, accordantly, ϰ2 = 14,815, p = 0.0001) were founded. Furthermore, it was shown different distribution of IGF-1 (CA repeats) gene polymorphism in man and woman. It was detected increasing of 19/20 genotype in newborn man compared with newborn woman (23,2 and 11,3%, accordantly), and significantly increasing of 19/20 genotype in elderly man compared with elderly woman (44,4 and 21,1%, accordantly, ϰ2 = 5,009, p = 0,025). A possible role of IGF-1 gene CA-polymorphism in ageing that is suggested. The prevalent Gly482Ser polymorphism of the PGC-1 gene has not been shown to be associated with life expectancy. It was detected increasing of Gly/Gly genotype in elderly woman compared with elderly man (51,0 и 27,3%, accordantly, ϰ2 = 4,063, p = 0,0438). The joint contribution of IGF-1 gene and PGC-1 gene is involved in ageing between groups of newborn and elderly people (20%, 41,8%, accordantly, ϰ2 = 4,858, p = 0,0275).

Keywords



About the authors

Svetlana V Potulova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: sveta_po2000@mail.ru

Oleg S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: olglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3. Russia

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

References

  1. Анисимов В. П., 2003. Молекулярные и физиологические механизмы старения//СПб.: Наука.
  2. Можайская И. А., Ахметов И. И., 2006. Ассоциация Gly482Ser полиморфизма гена PGC1A с аэробной выносливостью у спортсменов//Генетические, психофизические и педагогические технологии подготовки спортсменов. Сборник научных трудов, СПб., С. 91-94.
  3. Черных С. И., 2003. Новые аспекты в изучении роли гормона роста человека в регуляции процессов роста и развития//Научно-практический журнал «Медичний Всесвiт».Т.З. №2. С. 15-19.
  4. Barroso I., 2006. Meta-analysis of the Gly482Ser variant in PPARGCIA in type 2 diabetes and related phenotypes//Diabetologia. Vol.49. P.501-505.
  5. Bleumink G. S., Schut A. F. C., Sturkenboom M. C. J. M. et al., 2005. A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy//Heart, 2005. Vol. 91. P. 239-240.
  6. Bloor C. A., Knight A. R., Ravindra K. et at., 2001. Differential mRNA Expression of Insulin-like Growth Factor-1 Splice Variants in Patients With Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis//Am. J. Respir. Crit. Care Med. Vol. 164. N2. P.265-272.
  7. Cappola A. R., Xue Q. L., Femicci L. et at., 2003. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women//J. Clin. Endocrinol. Metab. Vol.88. №5. P. 2019-2025.
  8. Chakravarthy M. V., Pan Z., Zhu Y., Tordjman K., Schneider J. G., Coleman Т., Turk]., Semenkovich C.F., 2005. «New» hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis//Cell Metab. Vol. 1(5). P. 309-322.
  9. Cheurfa N., 2004. The Gly482Ser polymorphism in the peroxisome proliferatoractivated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men//Diabetologia. Vol. 47(11). P 1980-1983.
  10. Esterbauer H., 1999. Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC-1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression//Genomics. Vol. 62. P. 98-102.
  11. Finch С. Е., 2003. The biology of aging in model organisms//Alzheimer Dis. Assoc. Disord. Vol. 17(2). P. 39-41.
  12. Hara K. file:///2.HaraK , Tobe K., Okada T.,Kadowaki H. et al., 2002. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes // Diabetologia. N45. P. 740-743.
  13. Ling C., Poulsen P., Carlsson E., Ridderstrale M., Almgren P., Wojtaszewski J., Beck-Nielsen H., Groop L., Vaag A., 2004. Multiple environmental and genetic factors influence skeletal muscle PGC-1a and PGC-1 β gene expression in twins//J. Clin. Invest. V. 114. P. 1518-1526.
  14. Muller file:///A.Muller Y. L., Bogaidus C., Pedersen O., Baier L. A., 2003. Gly482Sermissense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians // Diabetes. Vol. 52(3). R 895-898.
  15. Rietveld L, Onori P.,Glaser S. S., 2004. A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height//Clinical Endocrinology. Vol.61. P. 195-203.
  16. Rivadeneira F., Houwing-Duistermaat J. J., Beck T. J. et al., 2004. The Influence of an Insulin-Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study//Journal of bone and mineral research. Vol. 19.
  17. Rivera E.J., Goldin A., Fulmer N. et ai, 2005. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine//Journal of Alzheimer's Disease. P. 247-268.
  18. Sonntag W. E., Lynch C. D., Cefalu W. Т., 1999. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-l on biological aging: inferences from moderate caloric-restricted animals//J. Gerontol. A. Biol. Sci. Med. Sci. Vol.54. N 12. P.521-538.
  19. VaessenN.,Heutink P.,Janssen J.A., Witteman J. C.M. et al., 2001. A Polymorphism in the Gene for IGF-I. Functional Properties and Risk for Type 2 Diabetes and Myocardial Infarction//Diabetes. Vol. 50. P. 637-642.
  20. Yazdanpanah M., Rietveld I., Janssen J. A. M. J. L. et ai, 2006. An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population//Am J Cardiol. N 97. P. 1274-1276. 21.
  21. Watson R. W., О 'Brien F., Coffey R. N., Fitzpatrick J.M., 2000. Insulin-like growth factor-1 alters apoptotic signalling in prostate cancer//Prostate Cancer Prostatic. Dis. Vol.3 P.42.

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Copyright (c) 2009 Potulova S.V., Glotov O.S., Baranov V.S.

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