«Ageingfeatures» analysis of IGF-1 and PGC-1 genes polymorphism



Cite item

Full Text

Abstract

Our goal was to investigate whether a polymorphism in IGF-1 gene (wild-type, 192 base pairs) and in the PGC-1 gene (Gly482Ser polymorphism) influence life expectancy. Different distribution of IGF-1 (CA repeats) gene polymorphism was shown. Increasing of 20/- genotype in elderly people compared with newborn group (26,7 and 44,1 %, accordantly, ϰ2 = 8,57, p = 0,0034) and decreasing of 19/19 genotype (51 and 27,9%, accordantly, ϰ2 = 14,815, p = 0.0001) were founded. Furthermore, it was shown different distribution of IGF-1 (CA repeats) gene polymorphism in man and woman. It was detected increasing of 19/20 genotype in newborn man compared with newborn woman (23,2 and 11,3%, accordantly), and significantly increasing of 19/20 genotype in elderly man compared with elderly woman (44,4 and 21,1%, accordantly, ϰ2 = 5,009, p = 0,025). A possible role of IGF-1 gene CA-polymorphism in ageing that is suggested. The prevalent Gly482Ser polymorphism of the PGC-1 gene has not been shown to be associated with life expectancy. It was detected increasing of Gly/Gly genotype in elderly woman compared with elderly man (51,0 и 27,3%, accordantly, ϰ2 = 4,063, p = 0,0438). The joint contribution of IGF-1 gene and PGC-1 gene is involved in ageing between groups of newborn and elderly people (20%, 41,8%, accordantly, ϰ2 = 4,858, p = 0,0275).

Keywords

About the authors

Svetlana V Potulova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: sveta_po2000@mail.ru

Oleg S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: olglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3. Russia

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

References

  1. Анисимов В. П., 2003. Молекулярные и физиологические механизмы старения//СПб.: Наука.
  2. Можайская И. А., Ахметов И. И., 2006. Ассоциация Gly482Ser полиморфизма гена PGC1A с аэробной выносливостью у спортсменов//Генетические, психофизические и педагогические технологии подготовки спортсменов. Сборник научных трудов, СПб., С. 91-94.
  3. Черных С. И., 2003. Новые аспекты в изучении роли гормона роста человека в регуляции процессов роста и развития//Научно-практический журнал «Медичний Всесвiт».Т.З. №2. С. 15-19.
  4. Barroso I., 2006. Meta-analysis of the Gly482Ser variant in PPARGCIA in type 2 diabetes and related phenotypes//Diabetologia. Vol.49. P.501-505.
  5. Bleumink G. S., Schut A. F. C., Sturkenboom M. C. J. M. et al., 2005. A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy//Heart, 2005. Vol. 91. P. 239-240.
  6. Bloor C. A., Knight A. R., Ravindra K. et at., 2001. Differential mRNA Expression of Insulin-like Growth Factor-1 Splice Variants in Patients With Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis//Am. J. Respir. Crit. Care Med. Vol. 164. N2. P.265-272.
  7. Cappola A. R., Xue Q. L., Femicci L. et at., 2003. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women//J. Clin. Endocrinol. Metab. Vol.88. №5. P. 2019-2025.
  8. Chakravarthy M. V., Pan Z., Zhu Y., Tordjman K., Schneider J. G., Coleman Т., Turk]., Semenkovich C.F., 2005. «New» hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis//Cell Metab. Vol. 1(5). P. 309-322.
  9. Cheurfa N., 2004. The Gly482Ser polymorphism in the peroxisome proliferatoractivated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men//Diabetologia. Vol. 47(11). P 1980-1983.
  10. Esterbauer H., 1999. Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC-1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression//Genomics. Vol. 62. P. 98-102.
  11. Finch С. Е., 2003. The biology of aging in model organisms//Alzheimer Dis. Assoc. Disord. Vol. 17(2). P. 39-41.
  12. Hara K. file:///2.HaraK , Tobe K., Okada T.,Kadowaki H. et al., 2002. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes // Diabetologia. N45. P. 740-743.
  13. Ling C., Poulsen P., Carlsson E., Ridderstrale M., Almgren P., Wojtaszewski J., Beck-Nielsen H., Groop L., Vaag A., 2004. Multiple environmental and genetic factors influence skeletal muscle PGC-1a and PGC-1 β gene expression in twins//J. Clin. Invest. V. 114. P. 1518-1526.
  14. Muller file:///A.Muller Y. L., Bogaidus C., Pedersen O., Baier L. A., 2003. Gly482Sermissense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians // Diabetes. Vol. 52(3). R 895-898.
  15. Rietveld L, Onori P.,Glaser S. S., 2004. A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height//Clinical Endocrinology. Vol.61. P. 195-203.
  16. Rivadeneira F., Houwing-Duistermaat J. J., Beck T. J. et al., 2004. The Influence of an Insulin-Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study//Journal of bone and mineral research. Vol. 19.
  17. Rivera E.J., Goldin A., Fulmer N. et ai, 2005. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine//Journal of Alzheimer's Disease. P. 247-268.
  18. Sonntag W. E., Lynch C. D., Cefalu W. Т., 1999. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-l on biological aging: inferences from moderate caloric-restricted animals//J. Gerontol. A. Biol. Sci. Med. Sci. Vol.54. N 12. P.521-538.
  19. VaessenN.,Heutink P.,Janssen J.A., Witteman J. C.M. et al., 2001. A Polymorphism in the Gene for IGF-I. Functional Properties and Risk for Type 2 Diabetes and Myocardial Infarction//Diabetes. Vol. 50. P. 637-642.
  20. Yazdanpanah M., Rietveld I., Janssen J. A. M. J. L. et ai, 2006. An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population//Am J Cardiol. N 97. P. 1274-1276. 21.
  21. Watson R. W., О 'Brien F., Coffey R. N., Fitzpatrick J.M., 2000. Insulin-like growth factor-1 alters apoptotic signalling in prostate cancer//Prostate Cancer Prostatic. Dis. Vol.3 P.42.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Potulova S.V., Glotov O.S., Baranov V.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 65617 от 04.05.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies