The analysis of association of the minisatellite UPS29 with Parkinson's disease

  • Authors: Suchkova I.O1, Shubina D.M1, Yakimovsky A.F2, Borisova E.V1, Eliseeva N.G1, Sasina L.K1, Baranova T.V1, Baranov V.S3, Patkin E.L1
  • Affiliations:
    1. Institute of Experimental Medicine, St. Petersburg, RF
    2. I. P. Pavlov First State Medical University, Saint-Petersburg, RF
    3. D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF
  • Issue: Vol 7, No 1 (2009)
  • Pages: 19-29
  • Section: Articles
  • URL: https://journals.eco-vector.com/ecolgenet/article/view/5449
  • DOI: https://doi.org/10.17816/ecogen7119-29
  • Cite item
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Abstract


The aim of this work was to identify new genetic markers associated with different forms of Parkinson's disease. A frequency of occurrence of different allele variants of minisatellite UPS29 localized in intron of centaurin p5 gene (CENTB5) was evaluated for patients with this pathology. The increase of frequency of UPS29 short alleles was observed for Parkinson's disease patients. This value depended on patient sex and age of pathology debut. Statistically significant difference with control was found only for females with early (30-50 years old) and late (> 60 years old) onset of Parkinson's disease. We suppose that UPS29 might be used as new genetic markers forearly (presymptomatic) diagnostics of some forms of Parkinson's disease.

Keywords



About the authors

Irina O Suchkova

Institute of Experimental Medicine, St. Petersburg, RF

Email: irsuchkova@mail.ru

Daria M Shubina

Institute of Experimental Medicine, St. Petersburg, RF

Email: iem@iem.spb.ru

Andrey F Yakimovsky

I. P. Pavlov First State Medical University, Saint-Petersburg, RF

Email: jakim@spmu.rssi.ru

Elena V Borisova

Institute of Experimental Medicine, St. Petersburg, RF

Email: doc_Lena@mail.ru

Nadezhda G Eliseeva

Institute of Experimental Medicine, St. Petersburg, RF

Email: iem@iem.spb.ru

Ludmila K Sasina

Institute of Experimental Medicine, St. Petersburg, RF

Email: sassina2001@hotmail.com

Tatyana V Baranova

Institute of Experimental Medicine, St. Petersburg, RF

Email: iem@iem.spb.ru

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

Eugene L Patkin

Institute of Experimental Medicine, St. Petersburg, RF

Email: elp44@mail.ru

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Copyright (c) 2009 Suchkova I.O., Shubina D.M., Yakimovsky A.F., Borisova E.V., Eliseeva N.G., Sasina L.K., Baranova T.V., Baranov V.S., Patkin E.L.

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