Prognostic capacity of the HIrisPlex genetic phenotyping system in the Belarusian population

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Abstract


Background. Externally visible traits such as iris and hair color are of interest in variants of arias of research from archeology and population genetics to forensic science. Recently a number of models have been developed to predict variants of human phenotypic characteristics. The most popular of them is the HIrisPlex system consisting of 24 SNPs, associated with human eyes and hair color.

Materials and methods. We used the HIrisPlex system for phenotyping of the Belarusian population. Allelic variants of the SNPs were genotyped by massive parallel sequencing. The analysis of the obtained data was performed using the free-available online resource https://HIrisPlex.erasmusmc.nl/.

Results. The comparison of the results of genotyping with actual data showed high accuracy of the system in determining blue and brown eyes (94.5% and 91.8% of correct predictions, respectively), and in identifying brown-haired (84.7%) and red-haired individuals (80%). The HIrisPlex system successfully  predicts iris and hair color in two most numerous phenotypic groups - "brown-haired with blue eyes" (BA=78.5%) and "brown-haired with brown eyes" (BA=85.5%).

Conclusion. The HIrisPlex system has a high prognostic ability  for some phenotypic characteristics in the Belarusian population. But for traits that are difficult identified, additional researchers are required.


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About the authors

Marina V. Seredenko

Institute of Genetics and Cytology, National Academy of Sciences of Belarus

Email: m.shinkevich@igc.by

Belarus, 27 Akademicheskaya str., 220072, Minsk

Junior Researcher

Svetlana I. Vakula

Institute of Genetics and Cytology, National Academy of Sciences of Belarus

Email: svettera@yandex.ru
ORCID iD: 0000-0002-2242-7107

Belarus, 27 Akademicheskaya str., 220072, Minsk

researcher

Marina N. Shapturenko

Institute of Genetics and Cytology, National Academy of Sciences of Belarus

Author for correspondence.
Email: marinashapturenko@gmail.com
ORCID iD: 0000-0003-4694-3197
SPIN-code: 4774-2805

Belarus, 27 Akademicheskaya str., 220072, Minsk

Dr. Sci. (Biol.), Associate Professor, Chief Researcher

Alexander V. Kondratsiuk

Institute of Genetics and Cytology, National Academy of Sciences of Belarus

Email: aliaks.k@mail.ru

Belarus, 27 Akademicheskaya str., 220072, Minsk

Junior Researcher

Sergey R. Borovko

State Forensic Examination Committee of the Republic of Belarus

Email: s_borovko@mail.ru

Belarus, Minsk

Chief Forensic Expert

Artur V. Lugovnjov

State Forensic Examination Committee of the Republic of Belarus

Email: s_borovko@mail.ru

Belarus, Minsk

Forensic Expert

Irena G. Gudievskaya

Belarusian State Medical University

Email: freedom-iren@mail.ru

Belarus, Minsk

postgraduate student

Olga V. Skrypnik

Belarusian State Medical University

Email: olgaskrypnik1986@gmail.com

Belarus, Minsk

Postgraduate student

Lyudmila N. Marchenko

Belarusian State Medical University

Email: liudmila.marchenko@gmail.com
SPIN-code: 1730-3625

Belarus, Minsk

Postgraduate student

Alexander V. Kilchevsky

Institute of Genetics and Cytology, National Academy of Sciences of Belarus

Email: Kilchev@presidium.bas-net.by
ORCID iD: 0000-0002-0175-9786
SPIN-code: 2496-4294

Belarus, 27 Akademicheskaya str., 220072, Minsk

Dr. Sci. (Biol.), Professor, Academician

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