ANALIZ EFFEKTOV PRODUKTsII GIBRIDNOGO BELKA Aβ-SUP35MC V DROZhZhAKh SACCHAROMYCES CEREVISIAE

Abstract


Аβ-пептид является основным компонентом амилоидных бляшек, вызывающих нейротоксический эффект при болезни Альцгеймера. Мы сконструировали дрожжевой штамм, содержащий плазмиду с гибридным геном Аβ−SUP35MC на фоне делеции хромосомной копии генаSUP35. Полученные данные свидетельствуют о том, что гибридный белок Аβ-Sup35MC является дрожжевым прионом.

Keywords



Ol'ga Evgen'evna Tsaponina

Artem Gennadievich Lada

Email: biotambovez@mail.ru

Aleksandr Anatol'evich Rubel'

Email: arubel@mail.ru

Viktoriya Vladimirovna Navolotskaya

Irina Tomosovna Petrova

Sergey Georgievich Inge-Vechtomov

Email: ingevechtomov@gmail.com

Aleksey Petrovich Galkin

Email: apgalkin@mail.ru

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Copyright (c) 2005 Tsaponina O.E., Lada A.G., Rubel' A.A., Navolotskaya V.V., Petrova I.T., Inge-Vechtomov S.G., Galkin A.P.

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