Analysis of UCPs, PPARs and PGC-1 gene polyorphism in elderly people from North-West region of Russia

Abstract


Polymorphism of PPARA G/C, PPARD +294Т/С, PPARG Pro12Ala, PGC-1 Gly482Ser, UCP2 Ala55Val and UCP3 C-55T genes in elderly people (group1) and control group (25-55 aged people) (group2) from North-West Region of Russia was studied by RLFP methods. Higher frequencies of T/C PPARD, Ser/Ser PGC-1 and C/C UCP3 genotypes in group1 compared to group2 were found. Furthermore, it was shown different distribution of PPARA, PPARD, PGC-1 and UCP2 genotypes in man and woman. We suggest that PPARA, PPARD, PGC-1 and UCP3 polymorphism is significant for survival.

Irina V Tarkovskaia

Saint-Petersburg State University., Saint-Petersburg, RF

Email: irena.88@inbox.ru 199034 Russia, Universitetskaya nab., 7-9

Oleg S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: olglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3. Russia

Tatyana E Ivashchenko

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: iagmail@ott.ru Mendeleyev Line, 3, Saint-Petersburg, 199034, Russia

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

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Copyright (c) 2011 Tarkovskaia I.V., Glotov O.S., Ivashchenko T.E., Baranov V.S.

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