Polymorphism of DNA repair genes (XRCC1, XRCC3, XPD, XPC) and risk of uterine myoma among women working in petrochemical complex

Abstract

Uterine myoma is a multifactorial disease in which the development involving both genetic and environmental factors. In this study we analyzed polymorphisms of genes excision repair (XRCC1, XPD/ERCC2, XPC) and repair of double-stranded DNA breaks (XRC 3) among women working at a large petrochemical complex of "Salavatnefteorgsintez". It is established that a minor allele homozygous for the minor allele genotype and polymorphism Gln939Lys (rs2228001) XPC gene are associated with the risk of uterine myoma (OR = 3.9 CI 1.001-18.13 for genotype and OR = 2.3 CI 1.36-3.77 for allele).

About the authors

Ol'ga Vadimovna Kochenova

Email: olga.elka@gmail.com

Makhmuza K Gainullina

Ufa research institute of occupational health and human ecology, Ufa, Republic of Bashkortostanб RF

Email: bakirov@anrb.ru Russia, Bashkortostan Republic. 450106, Ufa, St. Kuvikina street, 94

Tatyana V Victorova

Institute of Biochemistry and Genetics, Ufa Research Scientific Center RAS, Ufa, Republic of Bashkortostanб RF

Email: t_vict@mail.ru

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Copyright (c) 2011 Kochenova O.V., Gainullina M.K., Victorova T.V.

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