Genotoxic safety of synthetic food colours. Review

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Abstract

Food additives and food colours, in particular, are becoming more widespread in all countries. The review is devoted to a least studied problem of synthetic food colours safety assessment approved for use in the Russian Federation – to an analysis of their genotoxic effect (mechanisms, methods of determination and results of studies on various living objects). Results half-century study of the synthetic food colours genotoxicity demonstrated among studied colours there were none of them for which unambiguous research results were obtained, what allows us to conclude about the possibility of their real mutagenic and/or carcinogenic danger. It is shown that the problem of dose range selection for genotoxicity test, the associated problem of impurities control as well as approaches to test systems and selection of test objects are the key to ensure genetic/carcinogenic safety of food colours. These problems are aggravated by the fact that in the Russian Federation there is no any unified system for food colours genetic safety assessment. So, the main task of this publication is to prove an urgency of this system elaboration and to outline a group of main problems associated therewith.

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About the authors

Valentina V. Yurchenko

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: VYurchenko@cspmz.ru
SPIN-code: 4225-7898
Scopus Author ID: 14007498000

Cand. Sci. (Med.), Senior Researcher

Russian Federation, Moscow

Faina I. Ingel

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: FIngel@cspmz.ru
ORCID iD: 0000-0002-2262-6800
SPIN-code: 1013-7006
Scopus Author ID: 57205760994
ResearcherId: C-8899-2014

Dr. Sci. (Biol.), Main Researcher

Russian Federation, Moscow

Lyudmila V. Akhaltseva

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: LAhalceva@cspmz.ru
ORCID iD: 0000-0002-3619-3858
SPIN-code: 7049-0003
Scopus Author ID: 57138478700
ResearcherId: I-8204-2018

Cand. Sci. (Biol.), Senior Researcher

Russian Federation, Moscow

Mariya A. Konyashkina

Centre for Strategic Planning and Management of Biomedical Health Risks

Author for correspondence.
Email: MKonyashkina@cspmz.ru
ORCID iD: 0000-0002-8319-1329
SPIN-code: 7559-9045
Scopus Author ID: 8142882800

Cand. Sci. (Biol.), Research Associate

Russian Federation, Moscow

Nadezda A. Yurtseva

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: NYUrceva@cspmz.ru
ORCID iD: 0000-0001-5031-2916
SPIN-code: 8988-6769
Scopus Author ID: 12765611200

junior researcher

Russian Federation, Moscow

Tatyana A. Nikitina

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: TNikitina@cspmz.ru
ORCID iD: 0000-0003-0866-5990
SPIN-code: 9106-5076

biologist

Russian Federation, Moscow

Elena K. Krivtsova

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: EKrivcova@cspmz.ru
SPIN-code: 5297-2306

Research Associate

Russian Federation, Moscow

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