Genotoxic effects of antiepileptic drugs. Literature review
- Authors: Eremina N.V.1, Zhanataev A.K.1, Durnev A.D.1
-
Affiliations:
- Research Zakusov Institute of Pharmacology
- Issue: Vol 20, No 4 (2022)
- Pages: 295-313
- Section: Genetic toxicology
- Submitted: 20.07.2022
- Accepted: 13.09.2022
- Published: 24.12.2022
- URL: https://journals.eco-vector.com/ecolgenet/article/view/109400
- DOI: https://doi.org/10.17816/ecogen109400
- ID: 109400
Cite item
Abstract
Based on the selected criteria data from studies of the genotoxic activity of antiepileptic drugs in eukaryotic test systems in vitro and in vivo, performed by DNA comet assay, chromosomal aberrations and micronuclei assays, published in the period 1995–2022, were selected and summarized.
Among the 20 drugs reviewed, for one drug (N03AA05 Benzobarbital), there are no data on studies of genotoxic activity; for 7 drugs information is presented only as a summary on the FDA and EMA websites without primary data and information on experimental designs. Among the remaining 12 drugs, only three drugs (phenobarbital, valproic acid and levetiracetam) have information on in vivo studies, both by DNA damage assay and by cytogenetic methods. Based on known publications, it is impossible to draw reasonable conclusions about the genotoxic potential of individual drugs. The available data are fragmentary, incomplete and contradictory. It remains to state the facts of detection of genotoxic effects in individual drugs in separate studies. In general, there is no doubt about the potential genotoxic hazard of this group the drugs in.
Additional studies are needed to clarify the data on the genotoxicity of antiepileptic drugs including beyond the standard protocols. In the course of their implementation, one should take into account the possible tissue-specific manifestation of antiepileptics genotoxicity, as indicated by the facts of genotoxic effects detection in tissue cells that are not targets in classical genotoxic studies. The expediency of objectifying approaches when choosing a drug for safe therapy, taking into account information about its genotoxicity, is emphasized, and the prospects for possible studies on antigenotoxic prophylaxis in patients with epilepsy are pointed out.
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About the authors
Natalia V. Eremina
Research Zakusov Institute of Pharmacology
Author for correspondence.
Email: nnv1988@gmail.com
ORCID iD: 0000-0002-7226-5505
SPIN-code: 5224-1968
Cand, Sci. (Biol.), Senior Research Associate of the Laboratory of Drug Toxicology
Russian Federation, MoscowAliy K. Zhanataev
Research Zakusov Institute of Pharmacology
Email: zhanataev@academpharm.ru
ORCID iD: 0000-0002-7673-8672
SPIN-code: 7070-0510
Scopus Author ID: 6506103462
Cand. Sci. (Biol.), Leading Research Associate of the Laboratory of Mutagenesis Pharmacology
Russian Federation, MoscowAndrey D. Durnev
Research Zakusov Institute of Pharmacology
Email: addurnev@mail.ru
ORCID iD: 0000-0003-0218-8580
SPIN-code: 8426-0380
Scopus Author ID: 7006060753
Dr. Sci. (Med.), Professor, Corresponding Member of RAS; Head of the Department of Drug Toxicology and Pharmacology of Mutagenesis
Russian Federation, MoscowReferences
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