Analysis haemostatic system gene polymorphism in pregnant women without complications from Russia and Ukraine



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Abstract

Polymorphism of F5 1691G>A, F2 20210G>A, FGB –455G>A, ITGB3 1565Т>С, PAI1 –675 5G>4G, MTHFR 677C>Т genes in pregnant women from Russia and Ukraine was studied by biochip methods. No differences in distribution of F5, F2 and ITGβ3 gene polymorphism were detected. Higher rates of –455G/A FGB and –675 5G/4G PAI1 genotypes in ukrainians compared to pregnant women from Russia were found. Also variable distribution of MTHFR gene polymorphism in women from different countries was registered. The complex approach based on the calculation of relative “score” as a sum of relevant genetic polymorphisms has detected somewhat elevated risk of trombophilia for pregnant women from Ukraine compared to this one from Russia. 

About the authors

Elena S Vashukova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: vi_lena@list.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3, Russia

Andrey S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: anglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3, Russia

Maria D Kanaeva

Saint-Petersburg State University., Saint-Petersburg, RF

Email: kanaeva.masha@yandex.ru 199034, Saint-Petersburg, Universitetskaya nab, 7/9, Russia

Lubov B Polushkina

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: iagmail@ott.ru

Nadezhda A Shabanova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: iagmail@ott.ru

Pavel F Tatarsky

Institute of Molecular Biology and Genetics NASU, Kyiv, Ukraine

Email: livshits@imbg.org.ua

Elena N Nosenko

Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine

Email: iagmail@ott.ru

Beshir Mertil

Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine

Email: babich@mama.dn.ua

Irina A Zhabchenko

Institute of Pediatrics, Obstetrics and Gynecology NAMSU, Kyiv, Ukraine

Marina V Pokhitun

Institute of Pediatrics, Obstetrics and Gynecology NAMSU, Kyiv, Ukraine

Ludmila A Livshits

Institute of Molecular Biology and Genetics NASU, Kyiv, Ukraine

Email: livshits@imbg.org.ua

Marina S Zainulina

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: 199034, Russia, Saint Petersburg, 3, Mendeleyevskaya line

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

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Copyright (c) 2011 Vashukova E.S., Glotov A.S., Kanaeva M.D., Polushkina L.B., Shabanova N.A., Tatarsky P.F., Nosenko E.N., Mertil B., Zhabchenko I.A., Pokhitun M.V., Livshits L.A., Zainulina M.S., Baranov V.S.

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