Sandoglobulin in prophylaxis and treatment of septic complications after cesarean section

Abstract

Objective: To compare the efficacy of different types of IgG using in prophylactic and treatment of septic complications after Cesarean section.

Full Text

Methods: 85 women undergoing Cesarean section were divided into two groups. 15 women (study group) were given Sandoglobulin, 70 women (control group) - Roncoleukin. The postoperative period was monitored in each patient. The rate of septic complications, adverse effects and the length of hospitalization were compared in the groups. Results obtained in the two patient groups were compared by t-test or c2 -test, as appropriate.

Results: Septic complications were less severe in the study group -uterus subinvolution and endometritis prevalence. There were no such severe complications as metroendometritis or peritonitis. Uterus subinvolution were seen in 4,1% of the patients in the study group vs 9,1% in the control group (p<0,05), endometritis in 3% vs 6% (p<0,05), respectively. The average length of hospitalization was 9,4 days in the study group vs 13,8 days in the control group (p<0,01). There were no adverse effects related to Sandoglobulin administration. In the control group there were two cases of allergic reactions (shivering) resulted in stopping of Roncoleukin administration.

Conclusions: Sandoglobulin administration results in reducing of the rate of septic complications and the length of hospitalization. The tolerability of Sandoglobulin is very good. Therefore, using of Sandoglobulin is an effective method of prophylactic and treatment of septic complications after Cesarean section.