Antioxidants and adaptation in gestosis pathogenesis in pregnant women

Abstract

Objective. The purpose of the study was to estimate functional state changes of separate antioxidant system components in serum and whole blood in women with physiologic pregnancy in their I, II, III trimesters and in pregnant women with different clinical forms of gestosis.

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Methods. 320 patients with different forms of gestosis (edema, nephropathy (stages 1-3), preeclampsy and eclampsy) were clinically observed using modern clinico-physiological and biochemical methods. Women with normal pregnancy in their I (20), II (25), III (56) trimesters served as control.

Results. In all clinical forms of the pathology б-tocoferol deficiency and redox homeostasis disturbances in non-protein thiodisulfide and ascorbate systems were proved to be more obvious than the same blood factors in women with normal pregnancy in the III trimester.

Conclusions. On the basis of the date received the concept on antioxidant deficiency role in late toxicosis genesis in pregnant women is suggested. The suggested concept is proved by positive therapeutic effect observed while using antioxidants in complex treatment of the pathology studied.