The effect of benzodiazepin tranquilisators on the psychosomatic status of the high risk group of pregnant women

Abstract

Objective. The purpose of the study was to regulate the contractile activity of the uterus through the central nervous system and to have some psychotrophic effect.

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Methods. We used nosepam (a tranquilisator of 1.4-benzodiazepin type produced in Russia) in a dose of 0.01-0.02g in 32 women at 39-40 weeks pregnancy. The control group (32 women) received no nosepam.

Results. The effect of nosepam was estimated from its influence on the psychosomatic state and contractile myométrial activity of the pregnant women. The psychosomatic state was defined with the help of a scale, which was first designed in collaboration with the Psychological Department of St.Petersburg University (V.V. Abramchenko, T.A. Nemchin).

Conclusions. The data obtained suggest that administration of benzodiazepin compounds normalizes myométrial contractility, improves psychosomatic status and anxiety in pregnant women and prevents abnormal labor and delivery in the group of high-risk perinatal pathology. Nosepam has no negative effect on the fetus.