Humoral and mucosal immunity in uncomplicated and complicated EPH-gestos of pregnants

Abstract

Objective: to study the humoral and mucosal immunity in uncomplicated and complicated EPH-gestos of pregnants.

Full Text

Method: 66 women with uncomplicated (n=20) and complicated with EPG-gestos (n=42) of pregnancy were studied. In serum and cervical mucosa samples the level of Ig A, Ig M, Ig G were controlled.

Results: the concentration of serum Ig G in uncomplicated cases was 10,2 + 0,6 g/l, whereas the level of mucosal Ig A, Ig M and Ig G was 0,25 + 0,06 g/l; 0,19 + 0,06 g/l; and 0,60 + 0,03 g/l comparatively. The statistically significant (p< 0,05) increase in the level of serum Ig M and mucosal Ig M was detected in complicated cases. The degree of this increase correlated with the severity of toxemia in pregnant women. The level of serum Ig G was lowest in edema cases, Ig G in mucosa was not detected at all, whereas mucosal Ig A was increased in 1,7 once more in comparison with healthy pregnants.

Conclusion: we conclude that the results reflect the disturbance in protein metabolism in EPG-gestos and on other hand demonstrate the relative activation of the mucosal immunity.