Hyperbaric oxygenation as a method of intensive therapy of posthypoxic disturbances of cerebral bloodflow in neonates

Abstract

Objective: To assess effectiveness of hyperbaric oxygenation (HBO) in intensive therapy of posthypoxic disturbances of cerebral bloodflow (DCB) in neonates.

Full Text

Methods: HBO was used in 130 asphyxiated neonates. Antioxidant fermentative system, free radical oxygenation, permeability of membranes of erythrocytes, sorbtion ability of erythrocytes, ABG and neurosonography were assessed before and after 1, 2, 3 steps of HBO.

Results: HBO leads to 1,5-2-fold increasing of glutation peroxidase activity, changes of SOD and catalase are absent, 1,5-2 fold decrease of free radical oxygenation could be seen. HBO leads to normalization of permeability of membranes of erythrocytes, ABG, decreases cerebral edema and improves clinical condition of patients.

Conclusion: HBO increases adaptation of neonates with DCB, have detoxicative, membran estabilasing effect, reduces time of staying in intensive care unit to 2 days comparing with routine methods.