Factors of early ovarian cancer’s prognosis

Abstract

Objective: Dethe-rate from ovarian cancer is very high taking the first place among other localizations of gynecological cancer and the fifth place among all possible reasons of women’s death in develop countries in spite of development of modern diagnostics’ methods of early ovarian cancer (sonografy, magnetic resonance, computer tomography is not exclude that histological polymorphism of ovarian cancer can be one from other showings of pathogenesis factors, determining variety of clinical showings and disease’s course and influencing by this on the prognosis. Exploration of factors’ influence on early ovarian cancer’s prognosis present in this abstract.

Full Text

Methods: It contains data about 147 women, who were ill with borderline and malignant tumours of ovary 1 a, b, c, st. And treated since 1980 till 1995. The patients are ranged from 16-79 years (mean 46,1 years). All patients were exposed to surgical or combined treatment (operation and adjuvant chemotherapy). Regimen VAK, CMF, PVB, CAP were applied from 1-6 courses depending on histological tumour’s structure. Histological tumour’s exploration was passed according to international histological classification of surface epithelial tumours of the ovary (modified from Scully, 1979). Staging started with a careful laparotomy by FIGO classification (1987). Postoperation monitoring was passed in time of 3-5 years.

Results: The worst five-years results were disclosed with clear cell tumours (66,7%) as compared with serous, mucinous and endometrial tumours (92,9%; 90,0%; 93,3%) and with poorly-differentiated as compared with well-differentiated lesions, too. Methods of treatment did not influence on its results.

Conclusions: So there was conclusion about histological structure and differentiation have a deciding mean for prognosis for patients with early ovarian cancer.