Prophylaxis of fetoplacental insuffiency in the 1 trimester of pregnancy

Abstract

It is known that permanent threatening abortion in the 1 trimester is the reason of early fetoplacental insufficiency and fetal intrauterine growth retardation.

Aim: To evaluate the possibility of dydrohesterone use for prophylaxis of fetoplacental insufficiency in women with the history of habitual abortion.

Full Text

Methods: Clinical, hormonal, histological, ultrasound and doppler examination, mathematical analysis.

Object: 32 women in the 1 trimester of pregnancy, from the risk groups for miscarriage.

Results: Decreased concentrations of fetoplacental complex hormones were registered in 40,6% of women without signs of threatened abortion. In other cases, symptoms of permanent threatened abortion were diagnosed. Markers of urogenital infection were revealed in 46,9%.

Treatment of threatened abortion and hormonal disbalance correction with dydrohesterone were held according to standard scheme together with symptomatic therapy. Pregnancy progressed in 91% of cases. Normal hormonal status was shown in 77,7% of women and symptoms of threatened abortion disappeared in 90,6% of cases. Fetoplacental insufficiency was not diagnosed or was compensated in 90,7% of women.

Conclusion: Use of dydrohesterone in complex therapy of threatened abortion in 1 trimester helps to end the threat of abortion, to normalize hormonal status and it is effective in the prophylaxis of primary fetoplacental insufficiency.