Immunologic resistance syndrome

Abstract

A comparative study of the immune status of the inhabitants of the plain with the maritime climate being changed to the continental one (the Kaliningrad, Alma-Ata regions) and the natives of highlands (Zailijskij Alatau and the Pamirs) has boon undertaken.

The indices of the immune status for the Kaliningrad and Leningrad region inhabitants were found to be the following: SD3 content equals 45,3±1,6%, SD4 — 20,2±1,2%, SD8 ±14,7±0,9%, SD16 ±9,1%, SD4/SD8 relationship makes up 1,4±0,13. The relevant values for the foothills and highlands inhabitants showed more considerable fluctuations due to the climatic discomfort.

Full Text

Factors of non-specific immunologic reactivity were estimated reactivity were estimated: the monocyte content being 8, 07±0,6%, the phagocytic index of monocytes — 44,3±1,9%, a phagocytic number — 2,2±0,1%, an integral index — 1,004±0,053.

NST-test of monocytes is defined by the number of diphormasan-positive cells — 9,07±0,08%, the average cytochemical coefficient of reaction — 0,123±0,01, the aggregate index of luminescence by lysos in the monocyte cytoplasm — 295,3±8,1, and the monocytes ability of adhesion and splitting comprising respectively 56,2±1,4 and 35,07±0,8%. The expression level of receptors for Fe fragment of immunoglobulin and C3- fraction of the complement on the monocyte membrane comprised respectively 36,1±1,07 and 45,4±1,01%. The phagocytic activity of neutrophils was determined with the help of the following values: a phagocytic index — 68,05±1,8%, a phagocytic number — 4,6±0,2%, an integral phagocytic index — 3,15±0,18%; NST-test of neutrophils: the number of diphormasan-positive cells — 80,55±1,55%, the average cytochemical coefficient of reaction — 0,949±0,038.

The results received reveal that the majority of the people examined are characterized by the disfunction of the fermentai systems of the monocytic and macrophagal cells and the development of the oxygen-depend- able factors of the microbicidity of the phagocytic system. This is certain to be linked with a wide spreading of infections based on the malfunctioning of the mechanism of the bactericidal action.

The whole complex of typical malfunctions of the factors of the organism’s non-specific protection and reduced effectiveness of the phagocytic system ’s functions are suggested by us to be designated as a transitional syndrome of regional immunal hyporesistance. It reflects polypathogenetic malfunctioning of the organism’s protection systems and reduction of the reserve capabilities of the phagocytic part of the immunitas.