Condition of platelet part of hemostasis in diabetic mothers and their neonates

Abstract

Objective: To evaluate clinical condition and platelet hemostasis in diabetic mothers and their neonates.

Full Text

Methods: Aggregation of platelets in whole blood were assessed in women with I type diabetes mellitus (n=13), II type diabetes mellitus (n=2) and gestational diabetes (n=1) and their neonates in comparison with their clinical condition.

Results: Platelet aggregation in whole blood depends on severity of diabetes and its compensation during pregnancy. It decreases in severe decompensated I type diabetes. In neonates of such mother’s aggregation intensity is decreased in 3 times. In the case of compensated diabetes, aggregation activity is normal. In neonates with diabetic fetopathy amplitude of aggregation is 2,5-fold decreased, in comparison with healthy neonates.

Conclusion: Diabetes mellitus worsens postnatal adaptation of neonates and causes disturbances of platelet aggregation.