The role of chlamydial infection in perinatal pathology

Abstract

Objective: To evaluate the frequency, the peculiarities of the course of early neonatal period and the results of the treatment newborn infants infected with Chlamydia trachomatis.

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Methods: 246 newborn infants were examined. The isolation of Chlamydia trachomatis in swabs from the conjunctiva, pharynx, vulva of the neonates verified diagnosis of chlamydial infection. Polymerase-chain reaction as well as a cultural method was used. Antichlamydial antibodies in the blood of mothers and infants were assessed with immunofluorescent method.

Results: It was shown that newborns with chlamydial infection are formed 32% among the newborns with perinatal pathology. The following clinical forms of the intrauterine chlamydial infection were determined: 1) generalized infection with heavy affection of the CNS, lungs, heat, gastrointestinal tract, liver and other organs; 2) meningoencephalitis; 3) intrauterine pneumonia; 4) respiratory distress syndrome (in premature infants); 5) gastroenteropathy; 6) conjunctivitis. We have made a comparative estimation of efficiency of azithromycin and erythromycin in treatment of chlamydial infection in newborn infants.

Conclusion: The results show not only high clinical effectiveness of azithromycin, lack of adverse reactions, but also about it safeties.