Histology investigation of placenta in different types of retardation reflector-tonic reaction in newborns

Abstract

Objective: To specify influence of placental pathology on following CNS function retardation in newborns.

Full Text

Methods: 162 histology investigations of placentas in newborns with different types of retardation of reflectortonic reactions formation were examined. There are 40 investigations in newborns with dissociate retardation, 92 in newborns with regular retardation, 30 investigations with accordance reflector-tonic reaction of gestational age.

Results: In newborns with dissociate retardation was revealed significant alterations: in 87% of cases placental structure did not correlate to gestation age. Pathological immaturity of placenta was revealed in all cases. Structural disorders of shaggy chorion were revealed in 55%. Extent involutive-distrophycal changes were showed in 95%. Increasing of shaggy chorion fibrosis were revealed in 45% with higher content of fibrinoid in subchorionic compartment. Expressed circulatory disturbances were showed in 50% of cases. Inflammatory changes of placenta and extraplacental membranes were revealed in 95% cases. Placental insufficiency was revealed in all cases. Mentioned changes were revealed inconstantly and were much less noted in newborns with regular retardation and accordance reflector-tonic reactions of gestational age.

Conclusions: Results of our investigation showed, that coarse extent changes of placenta occur in the cases of reflector-tonic reaction dissociated retardation. Functional disturbances of mother-placenta-fetus complex are followed by these changes.