Distribution of HLA - antigens among patients with endometriosis

Abstract

Objective: To study the occurrence of human leukocyte antigens (HLA) in patients with endometriosis.

Full Text

Methods: 48 women with endometriosis at the age from 22 to 38 years were investigated. Subjects recruited at laparoscopy. HLA-A, В antigens were determined by standard lymphocytotoxic test. PCR-SSP method was used for HLA-DR typing. We detected 15 antigens locus A, 24 antigens locus В end 13 antigens locus DRB1. The control group consisted of 78 healthy women with regular menstrual cycle and without endometriosis

Results: The increase of the frequencies HLA-A24 was found compared to frequencies in the healthy women (33,3% vs. 20,9%), p<0,01. HLA-A3 and HLA-B18 were found significantly more rare (14,6% vs. 29,6%, p<0,05 and 4,2% vs. 14,2%), p<0,05, respectively than in control. The increase of DRB1* 16 was observed in women with endometriosis (11,6% vs. 2,6%, p<0,05). The risk of endometriosis development was greater in the patients with negative DRB1* 16—antigen (relative risk - 5).

Conclusions: HLA-DRB1* - antigen is predispose to development of endometriosis.