Distribution of HLA - antigens among patients with endometriosis
- Authors: Ioseliani T.G.1, Bubnova L.N.1, Bercos M.V.1, Bercos A.S.1
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Affiliations:
- D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
- Issue: Vol 48, No 5S (1999)
- Pages: 73-73
- Section: Articles
- Submitted: 16.02.2022
- Accepted: 16.02.2022
- Published: 15.12.1999
- URL: https://journals.eco-vector.com/jowd/article/view/100941
- DOI: https://doi.org/10.17816/JOWD100941
- ID: 100941
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Abstract
Objective: To study the occurrence of human leukocyte antigens (HLA) in patients with endometriosis.
Keywords
Full Text
Objective: To study the occurrence of human leukocyte antigens (HLA) in patients with endometriosis.
Methods: 48 women with endometriosis at the age from 22 to 38 years were investigated. Subjects recruited at laparoscopy. HLA-A, В antigens were determined by standard lymphocytotoxic test. PCR-SSP method was used for HLA-DR typing. We detected 15 antigens locus A, 24 antigens locus В end 13 antigens locus DRB1. The control group consisted of 78 healthy women with regular menstrual cycle and without endometriosis
Results: The increase of the frequencies HLA-A24 was found compared to frequencies in the healthy women (33,3% vs. 20,9%), p<0,01. HLA-A3 and HLA-B18 were found significantly more rare (14,6% vs. 29,6%, p<0,05 and 4,2% vs. 14,2%), p<0,05, respectively than in control. The increase of DRB1* 16 was observed in women with endometriosis (11,6% vs. 2,6%, p<0,05). The risk of endometriosis development was greater in the patients with negative DRB1* 16—antigen (relative risk - 5).
Conclusions: HLA-DRB1* - antigen is predispose to development of endometriosis.
About the authors
T. G. Ioseliani
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, St. Petersburg
L. N. Bubnova
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg
M. V. Bercos
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg
A. S. Bercos
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg