Bacterial vaginosis as manifestant of women’s immunodeficiency

Abstract

Objective: The immune status of fertile women with bacterial vaginosis (BV) in depending of the clinical features and treatment effectivity has been studied.

Full Text

Methods: There were 16,6% with symptoms, 20% with monosymptom, 63,4% with polysymptom course BV patient. The quantity of circulating lymphocytes different populations (T.I. Grishina, 1983), the concentration of serum A, M, G Ig classes (Mancini, 1963), the myeloperoxidase activity (MPO) of peripheric blood (PBN) and vagina mucous neutrophils (MVN) (Grechem-Cnolle, 1978) of 120 patients with BVand 40 healthy woman at the age from 18 to 45 years were determined. BV patients were treated by the two-staged method according to E.F. Kira (1993). Students t-test was used for the statistical analysis of obtained data.

Results: It has been shown that independing on the clinical type, the BV patient’s immune system has disbalance according to the secondary transitory immunodeficiency (STTD) type, expressed by the T-, B-lymphocytes number decreasing (p<0.001; p<0.01), O-lymphocytes number (p<0.001), Ig A and M increasing (p<0.001, p<0.01). There were the PBN MPO activity reductions (p<0.01) and the one of MVN — increasing (p<0.01). It has been established that the STTD extent directly correlates with the extent of clinical manifestations and treatment results. The clinical rehabilitation of patient with the persistent BV has been achieved only by the immunostimulators using.

Conclusion: The obtained data totality permits to consider that BV is one of the most important women’s STTD manifestant.