Probability labour activity after opioid analgesia in the preliminary period

Abstract

Objective: The basic purpose of the given work was the experimental and clinical proof of influence opioid analgetics on the contractility of myometrium and labour.

Full Text

Methods: Study contractility of isolated strips of myometrium. Outside tocography. 4 groups of comparison, 1-st with Promedol 20 women, 2-d with Fentanyl 22 women, 3-d with Tramal 28 women, 4-th with Moradol 18 women are allocated. 32 strips of myometrium have received on cesarean section from 8 women. In series of experiments the record of contractions of myometrium induced of Oxytocin on a background of each of opioid analgetics was carried out.

Results: The study of myometrial strips has shown, that opioids Fentanyl and Promedol cause authentic increase of frequency and decrease of amplitude of contractions at increase of basal tone. Tramal and Moradol caused increase of amplitude of muscular contraction, and Tramal considerably reduced basal tone (p=0.001). The data of clinical tocography have shown, that the application of Tramal in 90% (p < 0.05) cases resulted in development of regular labour activity on a background of treatment of the preliminary period. Moradol resulted to improve of labours in 72% (p < 0.05). Promedol and Fentanyl suppressed contractility of myometrium and only in 36% and 45% accordingly (p < 0.05) the transition of the preliminary period in regular labours was observed.

Conclusions: Opioid analgesia promotes regulation of labour activity and is acceptable to adequate treatment of the preliminary period and preventive maintenance of weakness in labours.