Progestogenic activity of new analogues of 17a-hydroxyprogesterone

Abstract

Objective: To estimate progestogenic activity of new synthetic compounds - analogues of 17a-hydroxyprogesterone and their capable to maintain the pregnancy in the rabbits experiments.

Full Text

Methods: Estrogenized immature female rabbits were administered per os the test substances (0,004-0,5 mg/kg b.w.). The uteri were histologically examined. The progestogenic activity was measured by the extent of secretory changes of the endometrium. Pregnant rabbits were ovariectomized 18 hours after copulation. On the day of ovariectomy and the next 6 days rabbits were injected subcutaneously by the test substances (0,25 mg/kg b.w.). Rabbits were killed on the 7 day of gestation. It was determined the presence of blastocysts in the uterus.

Results: It was shown that the test substances produced significant secretory transformations in the rabbit endometrium. Acetomepregenol, AMOLA are 26 times, phenylpropionate 28 times, butamepregenol 103 times more active than progesterone. It is revealed that test substances maintained pregnancies in all ovariectomized females.

Conclusions: The test substances are progestogens of high activity and may be used for elaboration of new preparations for obstetrics and gynecology.