Pathogenesis of perinatal pathology in mothers with genital chlamydia trachomatis infection (GCTI)

Abstract

Objective: To evaluate the state of humoral immunity disturbances in pathogenesis of perinatal pathology in pregnant women with GCTI.

Full Text

Methods. 48 term neonates and mothers with GCTI during pregnancy composed the main group. 16 healthy neonates and mothers composed control group. Immunomorphological status of placentas was assessed. The blood levels of IgA, IgM, IgG were tested by the method of radial immunodiffusion (Manchini). Circulated immunocomplexes (CIC) were assessed by immunofluorescent (IFA) method. IFA method and western - blotting method measured contents and functional activity of C3 component of complement respectively.

Results. 19 neonates from the main group were healthy (1 subgroup). Perinatal pathology was observed in 29 neonate (subgroup), C. trachomatis infection was determined in 6 neonates. Low concentration of IgG, reduced activation of C3 component of complement, high contents of CIC in blood was founded in neonates of 2 subgroup. In placentas of 2 subgroup were exposed fixated immunocomplexes with abundance of C3 component of complement.

Conclusion: Our investigations showed that perinatal pathology in neonates from GCTI mothers is a result of both intrauterine C. trachomatis infection and consequences of humoral immunity disturbances of the system “mother - placenta- fetus”.