Effects of endometrial thickness and uterine blood flow on IVF outcome

Abstract

Objective and methods. Research was undertaken aiming at determining what effect the condition of the endometrium on the day of the HG injection has on the results of the IVF.

Full Text

The research included: a multi-faceted statistical analysis of the results of 271 cycles of IVF; prospective complex research of the ultrasound characteristics of the endometrium and Doppler indicators of the blood flow in the vessels of the uterus (56 patients); and retrospective analysis of the process and outcome of 265 IVF pregnancies.

Results. It was established that within the IVF program, 70% pregnancies occurred when the thickness of the endometrium on the day of HG injection ranged from 9-12 mm. The thickness of endometrium significantly influenced the frequently of the occurrence of pregnancy, the frequency of implantation and that of multi pie-pregnancies (F=14,0; p, 0,001)

The lowering of the pulsation index (PI) indicators, and the intermittency or absence of the final diastolic flow rate in spiral artery before the HG injection, signify a poor prognosis for the occurrence of the pregnancy in the IVF program

In the group of patients with an endometrial thickness of less than 8 mm on the day of HG injection, the frequency of ectopic pregnancies (8,3%) and the frequency of early term spontaneous abortions (27,2%) were 3,5 times higher than the patients with an endometrial thickness of over 8 mm (2,4% and 7,8%, respectively).

Conclusion. The thickness of the endometrium and adequacy of blood flow in the uterine vessels are the factors which determine the results of the IVF program and influence the outcome of IVF pregnancies.