Termination of midgestation pregnancy using laminaria or intracervical prostaglandin E(2) followed by prostaglandin analogues
- Authors: Kravchenko N.F.1, Gurtovoi B.L.1, Ordzhonikidze N.V.1, Tioutiounnik V.L.1
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Affiliations:
- Research Centre of Obstetrics, Gynecology & Perinatology
- Issue: Vol 48, No 5S (1999)
- Pages: 90-90
- Section: Articles
- Submitted: 17.02.2022
- Accepted: 17.02.2022
- Published: 15.12.1999
- URL: https://journals.eco-vector.com/jowd/article/view/101027
- DOI: https://doi.org/10.17816/JOWD101027
- ID: 101027
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Abstract
Objective: The optimal regimen of medical termination of the second trimester pregnancy is still under development, but it likely to be characterized by a short induction-to-abortion interval, low incidence of side-effects and high acceptability.
Full Text
Objective: The optimal regimen of medical termination of the second trimester pregnancy is still under development, but it likely to be characterized by a short induction-to-abortion interval, low incidence of side-effects and high acceptability.
Methods: We conducted a prospective, randomized trial to evaluate the efficacy and safety of prostaglandin E2 and F2 alpha analogues intramuscular administration for second-trimester abortion in women intracervically pretreated with prostaglandin E2 (dinoprostone) gel (was given 12 hours before the intramuscular administration of prostaglandins) or one or more medium-thick laminaria tents (were used in a single application for 12 hours).
Results: 250 women requesting termination of second trimester pregnancy were randomized into 4 groups depending on different drug combinations. The mean age and parity of the women and the mean gestational age of the 4 groups were comparable. The median abortion interval was 8.2 hours and the cumulative abortion rates at 24 h was 95%. The total dose of the prostaglandins required to induce abortion and the incidence of side effects or analgesic requirement were significantly less due to cervical priming.
Conclusion: Combination of dinoprostone or laminaria priming of the cervix prior to the synthetic prostaglandin administration is an easy, practical, reliable and safe method of pregnancy termination in midgestation.
About the authors
N. F. Kravchenko
Research Centre of Obstetrics, Gynecology & Perinatology
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
B. L. Gurtovoi
Research Centre of Obstetrics, Gynecology & Perinatology
Email: info@eco-vector.com
Russian Federation, Moscow
N. V. Ordzhonikidze
Research Centre of Obstetrics, Gynecology & Perinatology
Email: info@eco-vector.com
Russian Federation, Moscow
V. L. Tioutiounnik
Research Centre of Obstetrics, Gynecology & Perinatology
Email: info@eco-vector.com
Russian Federation, Moscow