Phenotypical characteristic of endometrial immunocompetent cells during polycystic ovary syndrome (POS) hormonal therapy

Abstract

Objective: To prepare the endometrium to stimulation ovulation cyclic hormonal therapy was administered to infertile women with POS: the 1-st group of patients (n=6) received glucocorticoids; the 2-nd group (n=9) received gestagens; the 3-rd group (n=5) received both gestagens and glucocorticoids. Thirteen patients with POS who didn’t get any therapy were considered as a comparison group (4-th group) and 5 fertile women became a control group.

Full Text

Methods: To determine women’s endometrial lymphoid and macrophagal cells subpopulations during therapy immunohistochemical assay was performed.

Results: It was observed that CD3 and CD4 levels were reduced among patients of 4-th group compared to women of control group. In comparison with 4-th group, patients of the 1-st group had elevated CD8, CD19; women of 2-nd and 3-rd group had higher levels of CD3, CD4, CD56, CD14; and those were significantly higher among patients of the 2-nd group.

Conclusions: Gestagens cause the elevation of macrophagal cells and endometrial large granular lymphocytes’ numbers, which have a unique ability to control early processes of implantation.