Histological study after administration of estrogens and acetylsalicylic acid on breast tissue

Abstract

Objective: The latest years showed the great increase of incidence of the breast cancer. Simultaneously the agents which play role in neoplasmatic processes are not clear. We have taken under considerations the fact that the numerous of patients who take estrogen preparations and the preparations of the acetylsalicylic acid is still increasing. We examined the influence of these preparations on the histological structure of the breast. Estrogen hormones are often used by young women as contraceptive preparations and by older women as replacement hormone therapy. The acetylsalicylic acid is a component of many analgetic and antipyretic drugs and it used in prevention of the cardiac infarct and in any other diseases.

Full Text

Methods: Our examinations were carried out on Wistar Strain rats. The animals were divided into four groups: К - control group, healthy rats - 30 animals; A - animals, which were injected long-term activity estrogens, one time per week for one month, i.m., at a dose of 1,5 mg per 100 g of weight of rat - 30 animals; В - animals which were treated with acetylsalicylic acid, one time per day for one month, at a dose of 340 mg per 100 g of weight of rat, per os - 30 animals; C - animals which received estrogens and acetylsalicylic acid combined - 30 rats.

Results: On the base of our experiment we can concluded that the therapy of estrogens leads to disturbances of the normal structure of the mammary gland.

Conclusion: The administration of estrogens and acetylsalicylic acid simultaneously may lead to decrease intensity of disturbances of the breast.