The efficacy of recombinant FSG ovulation induction in normogonadotropic infertile women

Abstract

Objective: To study the efficacy of recombinant FSH ovulation induction in normogonadotropic infertile women.

Full Text

Methods: Puregon was used for 24 cycles of ovulation induction in 20 anovulatory infertile women. The average age of them was 28,3 years, lasting of infertility - 3,5 years, average level of FSG - 5,0 IU/L LG -10,2 -IU/I, estradiol- 158 pmol/l.

Results: The efficacy of ovulation induction were 40% pregnancy per women and 33% per cycle, that can be compared with the efficacy of hMG treatment. All patients transferred the treatment well, the frequency of OI-ISS developing occurred in 10% of cases. We noted no cases of undeveloping or multiple pregnancy. In 25% of women parameters of cycle, induced with Puregon had no differences with normal menstrual cycle - I periovulatory follicle, spontaneous ovulation, and average number of estradiol in periovulatory period - 500-600 pmol/l.

Conclusions: Ovulation induction using recFSG has more advantages than hMG. This happens because of the better physiologic parameters for the follicular development and the less risk of complications appearing. The recFSG can be used for ovulation induction in PCOS women.