Functional activity of thyroid gland of women with physiological pregnancy and with combination late gestosis

Abstract

Objective. The aim of the work was the investigation of functional activity of thyroid gland of women with physiological pregnancy and the nature of disorders of functions of thyroid gland of pregnant women with late combination gestosis.

Full Text

Methods. Thyroid hormonal status was investigated in 56 pregnant women with chronical infectional inflammatory extragenital and genital diseases, whose pregnancy was complicated by late gestosis, 36 women had gestosis of light degree and 20 women had gestosis of serious degree. The group under control consisted of 16 women with normal pregnancy. The hormonal tests of diagnostics offunction of thyroid gland were used. Serum total thyroxin (T₄), total triiodothyronine (T₃) were radioimmunoassayed in 72 women. The standard sets of medical substances of the firm “Immunotech” (Chekhia). The results are tested by the method of the variational statistics and correlation analysis.

Results. According to the results of the investigation of thyroid status in physiological normal pregnancy the function of thyroid gland is stimulated, T₃ —2,63±0,21 nmol/l, T₄ —141,9±8,41 nmol/l. Increase of functional activity of thyroid gland was revealed by investigations of indexes of thyroid hormones in women with late combinational gestosis of light degree - T₃ —2,81±0,11 nmol/l, T₄ —154,23±7,16 nmol/l. The authentity of the differences as to healthy pregnant women has not been found (p > 0,05). The considerable decrease of content of total triiodothyronine and total thyroxin was marked in pregnant with serious degree of combinational gestosis - T₃ —1,04±0,11 nmol/l, T₄ —66,10±6,59 nmol/l. The differences among groups are authentic (p< 0,05).

Conclusion. Chronical inflamatory genital and extragenital diseases influence on thyroid function and represent unfavorable prognostic criterion of the development of late gestosis. Taking it into consideration women with chronical inflamatory pathology, must be entered into “the group of risk” because of the development of gestosis. Dysfunction of thyroid gland is a marker, confirming participation of endocrine factors in the development of gestosis. Interconnection of hormonal activity of thyroid gland, reflecting, the degree of breaking of compensatory adapted process in the organism of pregnant, so the functional state of the gland is the diagnostic criterion of gravity of gestosis. Taking into consideration above mentioned the functional state of thyroid gland must be used as a criterion of prognosis of flow and outcome of pregnancy.