Increased phenotype frequencies of human leukocyte antigenes class II via a possible mechanism of relative risk of endometrial adenocarcinoma

Аннотация

Objective: Previous data have shown association between HLA phenotype and cervical cancer. The aim of our study was whether identify of HLA class II alleles to correlate with relative risk of endometrial adenocarcinoma (EA).

Полный текст

Methods: We typed by polymerize chain reaction-sequence specific primers (PCR-SSP) technique (HLA- DRB1*01-16, DQB1 *0201-0608, DQAl*0101-0601 alleles) of 46 patients with EA and 78 healthy subjects. Features are calculated using c2 test, and also relative risk (RR), ethyological fraction (EF) and preventive fraction (PF).

Results: Increased phenotype frequencies of HLA-DRB1*03 and DQB1*0201 are estimated from patients with EA (39,1% and 41,3%) comparing with healthy subjects (12,8%) and 24,4%, RR are 4,37 and 2,19, EF are 0,139 and 0,103, p<0,001 and 0,05, respectively. Decreased phenotype frequency of HLA - DRBI *01, DRB1*04, DQB1*0301 and DQAl*0301 are estimated from patients with EC, RR are 0,14, 0,12, 0,25 and 0,35; PF are 0,114, 0,125, 0,151 and 0,166, respectively, (p<0,05). There were no alleles of HLA-DQAl*0401 from patients with EA comparing with healthy subjects (0% and 7,7%, respectively), but there are no significant differences between both groups by c2- test, (p<0,1).

Conclusion: Eventually, it's conceivable that increased phenotype frequencies of HLA class II alleles can be used to identify relative risk of EA. For clinical application, however, these indices are to be combined with features of anamnesis and appreciation of influence environmental factors.