Can antibiotics be teratogenic?

Abstract

Objective: Gestation is a very special period for women. One of the threats at this time is bacterial infection. The presented experiment aimed to evaluate influence of two marketed antibiotics: Timentin (beta lactam carboxypenicillin combined with beta-lactamase inhibitor) and Adriblastin (doxorubicin hydrochloride), antibiotic cytostatic.

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Method: 188 Wistar rat females of 200-250 grams weight fertilized and 653 fetuses were delivered and examined. Following experimental groups were created: Timentin i.p.) intraperitoneally at doses 1- 32,0, II -320,0, III-3200 mg/kg body weight (b.w.) respectively, Adriblastin (i.p.). 16 mg/kg, b/w. Parallel three control groups were made: Kl-0,9% NaCl i.p. lml/kgb/w., K2- distilled water i.p-.lml/kgb/w, K0- received either no created. Drugs were administrated between 8 and 15 day of gestation and 21 days of gestation decapitations were performed. Fetuses were evacuated by cesarean section. Macroscopic evaluation of fetuses and placentas was done. Part of fetuses were dissected to observe changes in internal organs. Another part was stained in Dawson's methods to watch their skeletions changes.

Results: Adriblastin decreased weight gaming of females between 1-21 day of gestation in comparison to control groups. In Adriblastin group weight increase was 23,67±5/14 g, what is only 21,3% weight increased in females of control groups. Adriblastin increased number of early and late resorption. This gave a significant increase of post implantation mortality index— it was 37,25%. In fetuses there occurred heavy development defects: spina bifida, brain hernia and tongue hypertrophy ancylodactyly of 3 and 4 finger.

Conclusions: Adriblastin was toxic for mothers and fetuses. From the obtained results we can state the Timentin alone does not act embryo toxically and teratogenically.