Cervical pathology in women infected with oncogenic types of human papillomavirus

Abstract

Objective: We determined frequency and nature of cervical pathology in women infected with oncogenic types of Human Papillomavirus (ОТ HPV).

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Methods: 350 women with cervical pathology and 50 women without it were investigated. ОТ HPV were detected by means of Hybrid Capture 2 and PCR. All women underwent colposcopic and oncocytologic examination.

Results: 27,7% of women with cervical pathology and only 5,4% of women without it were infected with ОТ HPV. In women infected with ОТ HPV in 23 cases we revealed primarily cervical displasia (among them in 11 cases — mild, in 6 — moderate, in 3 — severe displasia, in 3 — carcinoma in situ). Quantitative detection of HPV demonstrated correlation between HPV viral load and frequency and severity of displasia: when viral load was less then 100 DNA copies/mkl in investigated sample no displasia was revealed (in 80% of cases) or mild displasia (20%). In viral load 100-750 DNA copies/mkl no displasia was revealed in 20%, mild displasia — in 40% and moderare displasia in 40% of cases. When viral load was more than 750 DNA copies/mkl no displasia was revealed in 10%, mild — 40%, moderate — in 30%, severe displasia or carcinoma in situ — in 40% of cases.

Resume: All women with cervical pathology should be investigated for the detection of ОТ HPV. Viral load detection can be an additional critérium for patients screening who are required corresponding diagnostic and treating procedures.