Immune system and preeclampsia

Abstract

It is known, that there are two different ways of development of immunocompetent cells by the activation of immune system. The first way is the proliferation and differentiation cells with their following capacity to realise of effeators functions, the second way is programm death of cells - the apopthosis.

Full Text

Study design: We investigated the functional state of immune system and markers of apopthosis in patients with normal pregnancies (13) and those patients with pregnancies complicated by severe preeclampsia with decompensation offoetoplacential insuffiency and stillbirth (5). The ages of the patients ranged from 16 to 35 years old, the gestational ages - from 24 to 32 weeks. We used the method of FACSCalibur Flow Cytometry System and system of monoclonal antibodies by “BECTON DICKINSON” in our investigation.

Results: Our results provide evidence of decreases the concentration of all lymphatic cells populations and subpopulatios in the venous blood in patients with severe preeclampsia compared with the normal women, includiny markers activation of the immune system and cells of “memory”.

The apopthosis markers were diagnosed in all pregnancies, but in case of the most concentration of those cells, stillbirth tooke place before manifestation of the severe preeclampsia.

Conclusion: The immune system of pregnant women with severe preeclampsia complicated by stillbirth is characterised by the asthenisation of all populations and subpopulations lymphatic cells and by apopthosis.