Indices of the natural killer cells cytotoxic activity and interferon values in patients with uterine myoma
- Authors: Shevchucova N.F.1, Seikov S.A.1, Kramareva N.L.1, Pigina T.V.1
-
Affiliations:
- D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
- Issue: Vol 48, No 5S (1999)
- Pages: 145-145
- Section: Articles
- URL: https://journals.eco-vector.com/jowd/article/view/101426
- DOI: https://doi.org/10.17816/JOWD101426
- ID: 101426
Cite item
Full Text
Abstract
Objective: The state of the system of immunological is of great importance for pathogenesis of uterine myoma as of any process of tumors growth.
Full Text
Objective: The state of the system of immunological is of great importance for pathogenesis of uterine myoma as of any process of tumors growth.
Methods: 56 patients were examined to study their clinical and laboratory data, total serum interferon, the ability of peripheral blood leukocytes to synthesize a/b and g-interferon, cytotoxic activity of natural killer cells.
Results: the cytotoxic activity of natural killer was low in 27% of women, and all of them had either fast growth of the uterine myoma (with nodes more than 5 cm in diameter) or myoma recurrence after myomectomy. High positive correlation was found between the patients age and the ability of peripheral blood leukocytes to produce g-interferon (correlation coefficient = 0,44), between the size of a myomatic node and indices of the functional activity of natural killers (c.c. = 0,35), between the ability of peripheral blood leukocytes to produce a/b-interferon and functional activity of natural killer cells (c.c. = 0,32)
Conclusion: So, the growth of uterine myoma can be predicted indirectly by the showings of cytotoxic activity of natural killer cells and by the ability of peripheral blood leukocytes to produce g-interferon.
About the authors
N. F. Shevchucova
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, St. Petersburg
S. A. Seikov
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg
N. L. Kramareva
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg
T. V. Pigina
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg