Determination of ecological situation in a region by indices of the female reproductive function in the premenopausal period

Abstract

Objective: To evaluate clinical, echographic and hormonal features of premenopausal period in connection with ecological peculiarities of a region.

Full Text

Method: 43 women who live in ecologically favorable suburban region of St.-Petersburg and 33 residents of ecologically unfavorable industrial region with remaining menstrual cycle (at the age of 45-55) were examined. Besides ordinary clinical survey, ultrasound investigation of small pelvis and mammary glands was made; FSH, LH, progesterone and E2 levels were analyzed by an immunofermentative method.

Results: In women of ecologically unfavorable regions and in residents of ecologically favorable regions the following was found: number of cycles with insufficient luteal phase (with progesterone level not exceeding 20 nmol/l was 15 (45.4%) and 13(30.2%), respectively; a decrease of the follicles number in 29(48.3%) and 24(33.3%); dysfunctional uterine bleedings in 12(36.6%) and 10(33.3%); mean basal FSH levels 15.4(3.8 IU/l and 10.8(3.4 IU/1; LH - 17.7(9.1 IU/1 and 72(1.1 IU/1; E2 - 172.7(17.9 IU/1 and 295.9(44.4 IU/l; flbroadenomatous changes of mammary glands in 48 (80%) and 27 (37.5%) women, respectively. All differences, besides ones of the uterine bleedings are statistically significant (p<0,01).

Conclusion: The peculiarities of premenopausal period may be used for the determination of ecological situation in a region.