The role of nitroglicerin in obstetrics

Abstract

Objective: Discovery of the nitric oxide role as messenger of smooth muscle relaxation mechanism (myometrium too) is evristical. Several cases of nitroglycerin administration relaxation as a method of choice in removal of remained placenta as well as in cesarean section were described.

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Methods: To control contractile uterine activity in pregnant women with a pathologic preliminary period, we successfully used sublingual application of Nitrolingual aerosol (Germany) with prolongation of the nitrate effect by the Deponit 5 system (Germany).

Results: As little as five minutes after aerosol application tocography revealed a decrease in uterine contraction frequency, duration, and intensity.

Conclusions: By effecting post- and preloading and lowering the resistance of spiral arteries, vasodilators provided increased intensity of placenta circulation, which had a great importance for ante- and intranatal care of the fetus and newborn. Rapidness of action onset, minimal risk of side effects development their, narrow spectrum allow to use the drug widely in pregnant with extragenital pathology and abnormal uterus contractility.