New approaches to treatment of mixed virus infection combined with autoimmune reactions in gravidae

Abstract

Examination has carried out in 344 gravidae with mixed virus infection (Herpes simplex virus, Cytomegalovirus, Epstein-Barr virus). The patients have screend for specific antiviral antibodies, antibodies to chorionic gonadotropin (hCG) and lupus anticoagulant (LA). We have studied interferon status (IFS) and cellular immunity parameters to select optimum schemes for nonspecific antivirus therapy.

Full Text

The relationship between activity of autoimmune reactions and reactivation of virus infection were obtained. Antibodies for hCG were detected in 30.8% of patients and LA-in 19%. The research has established that IFS was disordered in all patients. Therapy with use of a-2 Interferon (viferon) has promoted immune correction and correction of IFS, has decreased activity of autoimmune reactions and has prevented perinatal complications.