Placental a1 - microglobulin and fertility a1 - microglobulin in diagnosis intrauterine infections

Abstract

Objective: To assess the clinical significance placental proteins in diagnosis of intrauterine infection.

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Methods: Placental - microglobulin (PAMG - 1), and fertility a₁ - microglobulin (FAMG) were measured by enzyme immunoassay and solid - phase sandwich method with monoclonal antibodies. The results were processed by varational statistics methods using standard Windows-95 software.

Results: 68 pregnant women were examined at 32-40 weeks. 48 of these presented with intrauterine infection and 20 were controls. A significant increase of fertility a₁ - microglobulin concentration and decrease of placental a₁- microglobulin in amniotic fluid and in the blood serum pregnant women in intrauterine infection.

Conclusions: Assessment of placental protein helps define the criteria of diagnosis and prediction of intrauterine infections and predict the child’s status at birth.