Perinatal outcomes in pregnancies with pathogen of cytomegalovirus and herpes simplex detected in preterm placenta

Abstract

Objective: 182 cases of women with herpes simplex virus and cytomegalovirus infections were examined to study the peculiarity of their pregnancy, delivery, status of fetus and neonates in comparison with functional condition of fetal placental complex and morphologic changes in afterbirth.

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Methods: The morphological study was carried out by: 1. light microscopy; 2. immunohistochemistry, using indirect immunofluorescence with monospecific antibodies; 3. ultramicroscopy.

Results: Sings of HSV infection were detected in 24.5%, CMV infection - in 15.3% & combained HSV & CMV - in 61.2%. It was found, that the HSV & CMV infections results in significant changes such as: characteristic viral inclusions, inflammation, vascular damage.

In our study it promotes to decrease of fetal and maternal blood flow in 17,6%, intrauterine growth retardation in 21,7%, olygohy dr amnion in 17,6%, hydramnion in 21,6 %, placental calcinosis in 54,4%, intrauterine hypoxia in 29,6% and infection diseases in newborns in 27,4%.

Conclusion: All morphological changes of afterbirth oblige to begin the pathogenetic therapy of newborns, which assists to reduce frequency of gravity form neonatal herpes.