Placental insufficiency treatment in patients with herpes virus infection

Abstract

Objective: To evaluate the efficacy of immunocorrective therapy in complex treatment of placental insufficiency in pregnant women with herpes virus infection (herpes simplex virus infection and cytomegalovirus).

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Methods: 77 cases with disease relapses and asymptomatic elimination of virus were examined.

Results: Discovered disorders in immune and interferon statuses allow to prescribe for these patients immunocorrective therapy. For this purpose, we have used intravenous injections of immunoglobulin (250 mg/kg) 3 times a day in I, II and III trimesters of pregnancy. We have also used rectal suppositories with viferon (which consist of 150 000 ME alpha-2b interferon) 2 times a day for 5 days since 28 to 34 weeks of gestation. Viferon suppositories consisted of 500 000 ME of alpha-2b interferon have been prescribed 2 times daily after 35 weeks of gestation. Totally, we use a 12 week course of weekly viferon.

Conclusions: It was found that this therapy leads to a firm normalization of immune and interferon status in pregnant women with herpes virus infection and improves the effect of complex treatment of placental deficiency in these patients.