Preoperative preparation with using of the Zoladex in combined treatment of uterine myoma in women with infertility

Abstract

Objective: The study of the efficiency of the Zoladex in combined treatment of uterine myoma in women with infertility.

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Methods: Zoladex was used during 4 months as a preoperative preparation of 73 infertile women with the uterine myoma. The control included 38patients with infertility and uterine myoma. To them was performed myomectomy without any medicament preparation. Both groups were compared according to the clinical data and the sizes of myomata (diameter varied from 4 to 8 cm).

Results: In Zoladex group the diameter of myomata reduced in average by 30%. All patients underwent myomectomy under laparoscopic conditions. Operative interventions in the main group were performed in a 1-3 weeks after the 4^th injection of Zoladex. It was found that the duration of the main steps of laparoscopic myomectomy: enucleation of myomata, coagulation of myoma’s bed was shorter in the main group. Blood loss in the main group was in average 120 ml. and in the control one 160 ml (P< 0.005). Difficulties in identification of the capsule in the process of enucleation of myomata were found in 11 (15.4%) women of the main group and in 5 (13,2%) of the controls. No postoperative complications were noted.

Conclusion: Zoladex is an efficient means for preoperative preparation of women with uterine myoma. Difficulties in identification of capsules in enucleation of myomata may not be caused by depot-preparations use but by some other reasons, maybe by the nature of myomata growth.