Indicators of interferon system in patients with acute pelvic inflammatory diseases

Abstract

Objective. The aim of the investigation was to study interferon status in 81 patients with acute pelvic inflammatory diseases (APIT).

Full Text

Methods. Analysis of our story revealed that radical decrease of a- (9-15 times) and g- (10-32 times) interferon production comparing with normal figures is a characteristic form of interferon deficiency. We also investigated indicators of the interferon status depending on etiological agent. Accordingly, patients were divided into 4 groups: group 1 - women with bacterial-chlamidial-virus association; group 2 - patients with bacterial-virus flora; group 3 - women with bacterial-chlamidial infection; group 4 - with mixed bacterial flora.

Results. Analysis of interferon status in different groups allowed to reveal decrease of a- and g-interferon’s indicators in all groups. But more significant depression of a- and g-interferon production was in the 1st group with bacterial-chlamidial-virus association. Level of the serumal interferon in the 4th group with mixed bacterial flora, was found within the normal limits because of low interferon-producing ability of bacterium. However, serumal interferon indicators were twice as high in other groups, where bacterial flora was accompanied by chlamidium and viruses, comparing with normal figures. Chlamidium and viruses are likely to stimulate serumal interferon production.

Conclusions. Thus association chlamidium and viruses with bacterial infection leads to more severe changes of interferon indicators.