The assesment of the reproductive function in women with bone loss

Abstract

It is known that cessation of estrogen secretion is well-accepted to have a major role in pathogenesis of bone loss. The aim of the study is to analyes the state of reproductive system of examined patients with osteopenia and great rist for fractures. We examined 150 histories of women patients with osteopenia and great risk for fractures. The average age of patients is 41,2+0,4 years. All the women were diagnosed using dual-energy x-ray absorptiometry. Tscore of bone mineral content is -2,13+0,07 SD in the zone L₁-L₄. The patients have the beginning of menstrual function at age 14,3+0,2 year. 6 % of them have disorders of menstrual cycle such as unregular menses, olygomenorrhea. The amount of pregnancies resulted in delivery is 1,8+0,3, resulted in abortions is 5,6+0,05.

Full Text

It is known that cessation of estrogen secretion is well-accepted to have a major role in pathogenesis of bone loss. The aim of the study is to analyes the state of reproductive system of examined patients with osteopenia and great rist for fractures. We examined 150 histories of women patients with osteopenia and great risk for fractures. The average age of patients is 41,2+0,4 years. All the women were diagnosed using dual-energy x-ray absorptiometry. Tscore of bone mineral content is -2,13+0,07 SD in the zone L₁-L₄. The patients have the beginning of menstrual function at age 14,3+0,2 year. 6 % of them have disorders of menstrual cycle such as unregular menses, olygomenorrhea. The amount of pregnancies resulted in delivery is 1,8+0,3, resulted in abortions is 5,6+0,05. The period between pregnancies were short, and 24% of women have interval between pregnancies resulted in delivery less than two years. The lactation period is 8,3+0,4 months. None of the women used hormone contraceptive aids. Menopause begins earlier then usual at 41,4+0,6 years. Only 28% of the patients have physiological menopause. 64% of them have become menopausal after surgical operations such as hysterectomia — 9%, hysterectomia with singl ovarioectomia - 13%, hysterectomia with total ovarioectomia — 42%. Some of the women (8%) suffered from earlier menopausa after mental stress. Endometriosis prevails (76%) among gynecological diseases that caused operation. Myoma presences in 13% cases, cysts of ovarium are more frequent — in 31% of the patients. Only 12% of the women received hormone treatment or hormone replacement therapy for 5, 6+0,1 months. According to the study such risk factors of bone loss as frequent pregnancies, long lactation period, early menopause, hysterectomia and ovarioectomia, untreated gynecological diseases have been discovered.